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The bridge from genes changed to cell function changed is still half-built, and most of the published work leans on dermal fibroblasts, with far less on the cardiac, lung, or joint varieties, which makes generalizing across tissue types shakier than it sounds

Possible reasons include the Washington State University patent holders not finding a pharmaceutical company willing to invest in development, the cancer biology concern with c-Met activation making development companies cautious, the preclinical effect sizes in rats not justifying the expense and risk of human trials, or other factors specific to drug development economics

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